Since 2000, there have been impressive, historic gains in malaria control. An estimated 3.3 million lives have been saved world-wide, a function of elevated political commitment and enhanced international mobilization. Against this backdrop, a new consensus has taken shape around the need to transition from emergency control to an overarching goal of global elimination of the disease. The CSIS Global Health Policy Center provides in-depth analysis of pivotal opportunities and challenges in the field of malaria control and elimination. Topics include what an elimination approach implies; what uncertainties it faces; and what it will demand politically, financially, scientifically, and institutionally.