Machine Intelligence (MI) is poised to create profound changes to our lives, jobs, and economy. In breadth and scale of impact, MI will rival or exceed past technological revolutions while potentially altering centers of economic power and regional and global influence. Many countries are already making significant policy decisions to prepare for the impact of MI and are investing in MI research and development to outpace allies and competitors across economic and national security dimensions. If the United States wants to avoid being left behind in the “MI Revolution” we need to develop a coordinated national strategy that covers research and development, industrial specialization, and the social impacts of these technologies. This report offers a framework for determining which guiding principles should shape U.S. policy in response to the growth of MI applications in defense, education, health care, and the economy. The authors offer recommendations for how the United States can maintain a competitive advantage in MI and navigate the risks and challenges associated with it.